Deutsche Bundesstiftung Umwelt: Construction of a recombinant biocatalyst for the production of phenylacetic acids and phenylethanols from styrenes
Sarah Hofmann, Anna Drechsel, Michael Schlömann, and Michel Oelschlägel
DBU
Abstract:
Numerous soil bacteria have been reported to be able to metabolize styrene via the pathway of sidechain oxygenation. This pathway comprises a styrene monooxygenase (SMO), which oxidizes styrene to styrene oxide, a styrene oxide isomerase (SOI), which converts styrene oxide into phenylacetaldehyde, and a phenylacetaldehyde dehydrogenase (PAD). The latter enzyme enables the oxidation of the aldehyde to the central metabolite phenylacetic acid [1]. In this study the construction of a recombinant biocatalyst under consideration of suitable SMOs, SOIs and PADs was intended because this pathway is of potential relevance for the biotechnological production of phenylacetic acids and similar compounds.
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