Drug Discovery
As a contract research organization we provide the full range of drug discovery chemistry services and offer integrated solutions
Taros’ international and diverse team has more than 180 years of pharmaceutical R&D experience. Collectively as a team, we worked on more than 120 biomolecular targets from all major gene families and across all main therapeutic areas. As a privately owned Contract Research Organization we are running our own state-of-the-art Drug Discovery Chemistry facilities with the option for:
- Medicinal chemistry from hit validation to candidate selection
- Computational chemistry and molecular modeling
- Compound library design and production
- Parallel chemistry for high throughput experimentation
- Route scouting, process development and scale up to pilot plant
- Partners for outsourcing disease biology, HTS, ADME, DMPK, X-ray crystallography
In Medicinal Chemistry research, we are working with a broadly experienced team on all biomolecular targets from any gene family in any therapeutic area. Our expertise…
We routinely apply computer sciences in computational chemistry approaches and apply methods for structure-based drug design, in case structural data of the target…
High quality library design requires chemical creativity and profound synthesis knowledge to achieve the highest possible molecular diversity. Our efficient production…
Process development
- We are transforming your ideas into products
- From early discoveries and R&D chemistry in the laboratory to pilot scale for your application testing
- Always considering economic and safety boundaries and conditions laid out for all stages of the project
Pilot plant manufacturing
- We are running our own state-of-the-art pilot plant facility
in Asia with access to a broad supplier network - Providing samples of your compounds and specialties
in pilot scale for your extended application testing - Large-scale synthesis and custom manufacturing opportunities
Analytical chemistry and
purification
purification
- Providing analytical services and quality control for your purpose
- Several spectroscopic methods available including NMR,FT-IR,UV/VIS, etc.
- Calorimetric methods to monitor reactions and processes at every of the project
Committed to customers and success, we use all drug discovery approaches
We are exploring entry points into drug discovery and medicinal chemistry projects in an unbiased manner. High-throughput screening (HTS) and focused screening yields typically good quality hits through additional counter screens to ensure hit validation. This approach allows for the highest level of serendipity. Our molecular design capabilities are following both, structure- and ligand-based designs, as well as peptidomimetic techniques. Chemogenomics and fragment-based screening focuses on phylogenetic trees and good experience has been made across gene families when binding sites have been preserved. Selecting starting points from literature or IP knowledge yields traditionally high success rates with a shorter path to proof of concept (PoC) in animal models.
- Rational molecular design techniques like structure- and ligand-based designs as well as peptidomimetic approaches
- Literature and patent-inspired approaches which traditionally ensure a high success rate as well as a short track to POC in disease models
- High-throughput screening (HTS), medium throughput screening (MTS) as well as focused screening provide high quality hits and allows serendipity
- Fragment-based lead generation may uncover multiple binding sites and induce transient binding pockets
- Target family approaches, respectively Chemogenomics to focus on phylogenetic trees, GPCR SST5 as a quite good example
