Design and Synthesis of 1,1-disubstituted-1-Silacycloalkane-based Compound Libraries

Ortega R, Sanchez-Quesada J, Lorenz C, Dolega G, Karawajczyk A, Sanz M, Showell G, Giordanetto F Bioorg

Bioorg Med Chem Lett 2015

Abstract:
The introduction of silicon in biologically-relevant molecules represents an interesting medicinal chemistry tactic. Its use is mainly confined to the fine-tuning of specific molecular properties and organosilicon compounds are underrepresented in typical screening libraries. As part of the European Lead Factory efforts to generate novel, drug discovery-relevant chemical matter, the design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries is described.

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