Loes M Stevers, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Tomas Obsil, Isabelle Landrieu, Ylenia Cau, Andrew J. Wilson,…
J. Med. Chem., Oct. 2, 2017 DOI:10.1021/acs.jmedchem.7b00574;
Modulators of 14-3-3 Protein-Protein Interactions Read More »
Pioneering ideas to improve antidepressant therapies are greatly required since existing antidepressants are moderately effective and the response rate in patients suffering from depression is approximately less than 50%. Moreover, 5-10% of patients show no response to treatments. Custom Research Organization (CRO) Taros…
Tackling unmet medical needs Read More »
Nature magazine article on compound acquisition Buying cheap can be very expensive in the end Compound acquisition: „Buying cheap can be very expensive in the end“, says Dimitrios Tzalis, CEO of Taros Chemicals and Chemistry Leader of the EU Lead Factory in Nature magazine 548, 485–488, doi:10.1038/548485a. Read the full article – “check your chemistry” About Taros Chemicals
Nature magazine article on compound acquisition Read More »
Sebastian A. Andrei, Eline Sijbesma, Michael Hann, Jeremy Davis, Gavin O’Mahony, Matthew W. D. Perry, Anna Karawajczyk,…
Expert Opinion on Drug Discovery, 12:9, 925-940, DOI:10.1080/17460441.2017.1346608
Stabilization of protein-protein interactions in drug discovery Read More »
F.Giordanetto, P.Jones, A.Nelson, J.Benningshof, G.Müller, A.Pannifer, S.van Boeckel, D.Tzalis
Comprehensive Medicinal Chemistry III 2017, pp 505-519 DOI.org/10.1016/B978-0-12-409547-2.12303-0;
Helena Kaitsiotou, Marina Keul, Julia Hardick, Thomas Mühlenberg, Julia Ketzer, Christiane Ehrt, Jasmin Krüll, Federico Medda,…
J. Med. Chem., 2017, 60 (21), pp 8801–8815 DOI: 10.1021/acs.jmedchem.7b00841;
Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT Read More »
Acquiring chemotypes beholding structural features of natural products, for instance high sp3 character, the synthesis of compound collections based on core-scaffolds of natural products presents a promising strategy in drug discovery…
Silvia Hüttner, Io Antonopoulou, Laura Leonov, Peter Jütten, Alexander Piechot, Paul Christakopoulos and Lisbeth Olsson
Taros
Synthesis of Antioxidants with Free and Immobilised Fungal Feruloyl Esterases Read More »
Anna Karawajczyk, Kristina M. Orrling, Jon S. B. de Vlieger, Ton Rijnders and Dimitrios Tzalis
Front. Med., Jan. 2017 DOI.org/10.3389/fmed.2016.00075
Taros Chemicals, a privately owned CRO focused on serving the needs of pharmaceutical, chemical, agrochemical and biotech companies, announced that in November this year, it achieved the benchmark of the delivery of 30,000 unprecedented chemical compounds to be used for…
Taros: 30,000 novel chemical compounds shipped to the ELF Read More »